Reduction or loss of LPL activity in endothelial cells led to impairment of tissue function in the body, it could reduce the uptake of lipoprotein-derived fatty acids, which can lead to metabolic diseases (e.g., hypercholesterolemia, diabetes, obesity, and most importantly, CHD) (22, 32–34). The gene discussed is LPL; the disease is obesity due to melanocortin 4 receptor deficiency.