Cardiotoxicity, which may lead to myocarditis, occurs mainly from polypharmacy, overdosage, and long pharmacotherapy with conventional disease-modifying antirheumatic drugs (DMARD), renal impairment, folate deficiency and biologic agents such as Tumor Necrosis Factor (TNF)-α blockers and IL-6 receptor Inhibitors [20]. Here, TNF is linked to myocarditis.