Furthermore, H19-derived miRNA-675 has been reported to inhibit the expression of tumour suppressor RB in colorectal cancer, promoting tumour growth (Tsang et al., 2010) and displaying cancer cell-proliferating activity in bladder cancer by inhibiting p53 activation and decreasing Bax/Bcl-2 ratio (Liu et al., 2016). This evidence concerns the gene TP53 and cancer.