Autoimmune and inflammatory consequences of rheumatoid arthritis such as cartilage erosion and destruction, synovial hyperplasia, inflammatory joint fluid and synovium, marginal bone erosion can be linked to the dysregulation of lncRNAs like HOTAIR, H19, LOC100652951, LOC100506036, LincRNA-p21, NR024118, C5T1, MALAT1, MEG3, NEAT1, ZFAS1, GAS5. This evidence concerns the gene HOTAIR and rheumatoid arthritis.