Tumour-associated macrophages (TAMs) are one of the most abundant leucocytes found in the tumour microenvironment, mainly recruited in their monocyte form by the cancer cells via secretion of chemokine signals like C-C motif chemokine ligands (CCL2, CCL18, CCL20), C-X-C motif chemokine ligands (CXCL12), VEGF-A etc., commonly differentiating into two conflicting subgroups–M1 and M2 macrophages. The gene discussed is VEGFA; the disease is cancer.