Astragaloside IV-mediated upregulation of TRHDE-AS1 was shown to be correlated with the decreased expression of key protein markers of tumour growth and metastasis like Proliferating Cell Nuclear Antigen (PCNA), MMP9 and MMP7, ameliorating breast cancer proliferation and migration (Hu et al., 2021). This evidence concerns the gene TRHDE and breast cancer.