Autoimmune and inflammatory consequences of rheumatoid arthritis such as cartilage erosion and destruction, synovial hyperplasia, inflammatory joint fluid and synovium, marginal bone erosion can be linked to the dysregulation of lncRNAs like HOTAIR, H19, LOC100652951, LOC100506036, LincRNA-p21, NR024118, C5T1, MALAT1, MEG3, NEAT1, ZFAS1, GAS5. The gene discussed is MALAT1; the disease is rheumatoid arthritis.