Vennin et al., in 2015 also demonstrated that increased H19 levels promoted the tumorigenesis of breast cancer via upregulation of its by-product, miRNA-675, which led to the decreased expression of ubiquitin ligase E3 family proteins - c-Cbl and Cbl-b (Vennin et al., 2015). The gene discussed is H19; the disease is breast cancer.