MEG3 also inhibited IL4/13 stimulated M2 polarisation as upregulation of MEG3 expression in M2-Bone Marrow-Derived Macrophages (M2-BMDMs) downregulated M2 markers like CD206, YM1, MRC and ARG1, ameliorating tumour proliferation in macrophage-Huh7 co-culture (Wei et al., 2023). This evidence concerns the gene MRC1 and neoplasm.