In hepatocellular carcinoma, MEG3 overexpression by the LPS/IFN-γ induced M1 macrophages demonstrated antitumor effects as MEG3 expression in the cancer cells was significantly reduced and increased expression of MEG3 by the M1 macrophages suppressed metastasis and angiogenesis of HCC cells by targeting miR-145-5p and downregulating the production of disabled 2 (DAB2) protein. This evidence concerns the gene MEG3 and hepatocellular carcinoma.