MALAT1 interacted with various miRNAs such as miR-145, miR-22-3p, miR-155, miR-503, miR-214, and miR-92a associated with plaque formation, inflammation, hypertension, angiogenesis, activates Wnt/β-catenin signalling causing increased endothelial-mesenchymal transition, promote lipid accumulation by stabilising SREBP-1c protein, leading to regulation of atherosclerosis and also play a huge role in myocardial infarction, inflammation and cardiac remodelling (Yan et al., 2020) (Table 1). The gene discussed is SREBF1; the disease is hypertensive disorder.