Ketamine dampened PVT1 expression in SKOV3 and OVCAR3 ovarian cancer cells in-vitro and suppressed cell growth by binding to EZH2, a subunit of polycomb repressive complex 2, resulting in the increased expression of cyclin-dependent kinase inhibitor p57 (Li et al., 2021b) and also promoted ferroptosis in liver cancer cells by targeting PVT1, causing overexpression of the downstream target of the lncRNA, miR-214-3p. The gene discussed is PVT1; the disease is liver cancer.