Associated with endothelial cells and cardiomyocytes in CVD; interacts with miRNAs (miR-145, miR-22-3p, miR-155, miR-503, miR-214, miR-92a); affects plaque formation, inflammation, hypertension, angiogenesis; stabilizes SREBP-1c protein; regulates atherosclerosis, myocardial infarction, inflammation, cardiac remodeling. Here, SREBF1 is linked to atherosclerosis.