Similar results were observed in normal THP-1 cells induced with IL4/13 as co-culture of the induced macrophages with Human umbilical vein endothelial cells (HUVEC) cells upregulated VEGF, Notch1, Dll4 and VEGFR2 expression in HUVEC cells, promoting migration and indicating the role of M2 macrophages in the angiogenesis of cancer cells (Han et al., 2021). The gene discussed is NOTCH1; the disease is cancer.