NFKB1 and inflammatory bowel disease: Inflammatory bowel disease (IBD) is an autoimmune disorder characterized by dysregulation of multiple immune-related pathways and cells, including the NF-κB signaling pathway, helper T (Th) cells, and regulatory T (Treg) cells (Chen et al., 2020; Committee FoCE, 1983; Chen Caiying et al., 2015; Committee FoCE, 2011).