As a regulator of gene transcription, Krüppel-like factor 8 (KFL8), plays a vital role in multiple cellular process such as differentiation, apoptosis, drug resistance and inflammation, and has been implicated in the progression of various neoplastic conditions including triple negative breast cancer (TNBC), lung adenocarcinoma, hepatocellular carcinoma, gastric carcinoma and osteosarcoma among others (Liu et al., 2017; Le Minh et al., 2023; Kumar et al., 2021). Here, KLF8 is linked to osteosarcoma.