JAK2 and cancer: IL-6 has been implicated as mediator of tumor progression and chemoresistance in multiple cancers such as NSCLC and colorectal cancer wherein IL-6 has been observed to modulate autophagy by inducing phosphorylation of BECN1 via the IL-6/JAK2/BECN1 signaling pathway (He and Li, 2024; Hu et al., 2021).