ERN1 and differentiated thyroid carcinoma: Actually, Xue et al. reported that morusin, a flavonoid obtained from white mulberry, induces ER stress on human epithelial ovarian cancer cells by upregulating the heat shock protein family A member 5 (HSPA5), the DNA damage inducible transcript 3 (DDIT3 or CHOP), the endoplasmic reticulum to nucleus signaling 1 (ERN1) and the α subunit of the translation initiation factor 2 (eIF2α) driving cells to a paraptosis-like cell death (Xue et al., 2018) and Zhang et al. observed that curcumin boosts ER stress-associated apoptosis on human papillary thyroid carcinoma cells (Zhang, L. et al., 2018).