Furthermore, despite the fact that ATF4 itself was not deregulated by Ocoxin in all the analyzed cancer models, it arises as a central protein in the correlation among the genes altered by the compound (except for KIF20A, RAD54L and ESPL1) in common in COAD, PAAD, PRAD and TNBC. This evidence concerns the gene ESPL1 and prostate adenocarcinoma.