SMO and breast cancer: Consistently, the expression of mesenchymal biomarkers N-Cadherin, Vimentin and Snail and cancer stemness biomarkers USP37, ALDH1, OCT4 and Smo/Gli-1 in BC cells was suppressed by CYT and markedly recovered by SRSF1 overexpression (Figure 4E and Supplementary Figure S3B).