Specifically, the combination of exosomal miR-382 and CEA in serum (AUC: 0.953) (Luo et al., 2021) and plasma exosomal miR-let-7f-5p combined with CEA and CYFRA21-1 (AUC: 0.981), have notable advantages in the diagnosis of NSCLC (Wang et al., 2020). The gene discussed is CEACAM5; the disease is non-small cell lung carcinoma.