SERPINA1 and osteoarthritis: Additionally, an analysis of the interrelationships among the investigated indicators of Osteoarthritis Exacerbation Characteristics was conducted, and a prognostic model was developed to predict the need for increased NSAID doses in patients with osteoarthritis and impaired glucose tolerance, based on factors such as VAS-P-after 3 months, OKS-F-after 3 months, HbA1c-after 3 months, C-peptide-after 3 months, CRP-after 3 months, HP-after 3 months, and α1-AT-after 3 months using binary logistic regression.