After myocardial infarction, a large amounts of DAMPs are produced by the damaged myocardial cells (125), including the nuclei of myocardial cells (such as HMGB1), cytoplasm (such as RNA), extracellular matrix (such as fibronectin), mitochondria (such as mtDNA), and contractile components (myosin) (126, 127), which triggers the sterile inflammatory response after myocardial infarction and ultimately activates a complete innate immune signaling pathway (128). This evidence concerns the gene HMGB1 and myocardial infarction.