Additionally, many markers we observed that defined our monocyte clusters (FABP5, FN1, IL1RN, CCL3, CCL4, CXCL8, CXCL3, IL1B) during transient, short-term CM stimulation, were elevated in either PD-L1pos or PD-L1neg TAMs isolated and sequenced from breast cancer (61). This evidence concerns the gene IL1RN and breast cancer.