CXCL9, -10, -11 are CXCR3 ligands, expressed by several different cells within a tumor, that recruit T-cells and NK cells, with CXCL9 and 10 primarily recruiting activated CD4+ and CD8+ effector cells and CXCL11 recruiting or promoting development of T-regs (53, 54). This evidence concerns the gene CD4 and neoplasm.