Emerging evidence highlights the pivotal role of CXCL1 in driving oncogenic processes and promoting the metastatic spread of malignant cells to secondary sites through dual mechanisms: orchestrating the recruitment and accumulation of immunosuppressive cells within the tumor microenvironment, and enhancing the invasive potential and metastatic capabilities of malignant cells (Lu et al., 2024; Yu et al., 2019; Liang et al., 2021; Lv et al., 2014; Zheng et al., 2023; Hayashi et al., 2023; Molinelli et al., 2023). The gene discussed is CXCL1; the disease is neoplasm.