Lv et al. (2022) found that entacapone has the potential to inhibit osteosarcoma via the FTO/DACT1 axis. In a nude mouse tibia orthotopic model, entacapone inhibited tumor growth in a dose-dependent manner, significantly reduced tumor volume and weight, and reduce the number of lung metastatic nodules. In addition Deng et al. (2022) suggested that AI-assisted technology could be widely used in the discovery and development of drug candidates. This evidence concerns the gene DACT1 and osteosarcoma.