CD44 and cancer: YAP/TAZ is a well-known proto-oncogenethat regulates the proliferation and division of tumor cells duringtumor development.26 Studies have shownthat YAP/TAZ plays a role in the metastasis of various cancer types,including breast cancer; therefore, inhibiting their expression inbreast cancer cells through RNA interference (RNAi) can affect multiplecellular pathways and inhibit tumor development.84−86 Here, we investigatedwhether encapsulating YAP/TAZ siRNAs in AKPC-siYT enhances therapeuticefficacy in CD44+ breast cancer cells.