MC3R and neoplasm: LNPs were locally administered for 1 week (3 times/weekduring week 2), followed by tumor measurements one week post-treatment(Figure 7d, week 3).Bioluminescence measurements (week 3) demonstrated that the AKPC-siYTgroup exhibited a lower signal than the MC3-siYT and PBS groups, indicatinga reduction in tumor size in vivo (Figure 7e,f).