Compared to MC3-LNPs, AKPC-LNPs exhibited significantlyhigher silencing potency of YAP, TAZ, and both, indicating that AKPC-LNPscan efficiently deliver siRNA to CD44+ breast cancer cells.We also measured the mRNA expression of YAP/TAZ downstream genes AMTOL2,CTGF, and CYR61 in breast cancer cells (Figures 4b and S9b). Here, CCN2 is linked to breast cancer.