MC3R and neoplasm: Compared with MC3-siYT, AKPC-siYTtreatment significantly decreased the volume of the 3D spheroids.Analysis of the spheroid volume of different groups on day 12 revealedthat treatment with MC3-siYT resulted in some spheroid volume decrease(reduced by about 40%) when compared with PBS, MC3-siNC, and AKPC-siNC.Importantly, exposure to AKPC-siYT resulted in the highest reductionof spheroid volume (reduced by about 70%), indicating significantinhibition of tumor growth.