Concerning the role of GEMIN5 in selective translation of histone mRNAs, it has been recently reported that flunarizine treatment (a calcium channel blocker used to treat neurological diseases) (Younis et al. 2010) produces a transient increase in GEMIN5 protein levels followed by a gradual increase in mRNA levels encoding the lysine demethylase 6b (Kdm6b), independently of SMN protein levels (Salman et al. 2024). The gene discussed is KDM6B; the disease is nervous system disorder.