To explore the potential relationship between hypoxia‐induced PDK1/LDHA expression and the occurrence of EMT in NP tissues, we conducted IHC and IF staining to assess the expression levels of HIF‐1α, PDK1, LDHA, and EMT markers in nasal tissues from control subjects and CRSwNP patients. Here, PDK1 is linked to chronic rhinosinusitis with nasal polyps.