The hypoxia‐induced EMT process has been shown to contribute to nasal polyposis in CRSwNP, mediated by HIF‐1α and phosphorylated Smad3 (pSmad3), leading to a loss of E‐cadherin and induction of α‐SMA.5 The gene discussed is SMAD3; the disease is chronic rhinosinusitis with nasal polyps.