Our results indicated that the number of HIF‐1α(+), PDK1(+), and LDHA(+) cells in the nasal tissues of CRSwNP patients was significantly higher than in control subjects, moreover, the numbers of HIF‐1α(+) and PDK1(+) cells in the ECRSwNP group were more higher than those in the NECRSwNP group (Figure 2A,C). This evidence concerns the gene HIF1A and chronic rhinosinusitis with nasal polyps.