At the same time, 11 of the 13 mapped genes overlapped with reported genes from previous methylome-wide association studies for association with cardiometabolic traits or diseases, including type 2 diabetes [39], ischemic heart disease [39], body mass index [40–44], waist circumference [41, 42], and fasting insulin [45] (Supplemental Table 12). This evidence concerns the gene INS and type 2 diabetes mellitus.