For instance, RBM15B- and IGFBP2-mediated GPX4 m6A modifications, along with NSUN5-mediated GPX4 m5C modifications, affect redox homeostasis, activate the STING pathway, and enhance anticancer immunity in colorectal adenocarcinoma (COAD) [50]. The gene discussed is GPX4; the disease is colon adenocarcinoma.