METTL3 and neoplasm: Additionally, METTL3 and the reader HNRNPA2B1 control the maturation of miR-146b by regulating its m6A modification, which promotes M2-TAM polarization via the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, reducing T cell infiltration, increasing immunosuppression, and ultimately advancing tumor progression in colorectal cancer [73].