Conversely, deletion of METTL3 or METTL14 in tumors increases the expression of signal transducer and activator of transcription (STAT)1 and interferon regulatory factor (IRF)1; the resulting elevated secretion of CXCL9 and CXCL10 recruits CD8 + T cells and natural killer (NK) cells into the TME in colorectal cancer [60]. This evidence concerns the gene METTL3 and colorectal cancer.