In conclusion, the o8G reader YBX1 increases circKIAA1797 stability and cytoplasmic distribution, and circKIAA1797 affects cuproptosis levels by regulating the FDX1-LIPT1-DLAT ternary complex and the opening and closing of the mPTP, which ultimately promotes the development of lung cancer. Here, YBX1 is linked to lung carcinoma.