TFE3 and alveolar soft part sarcoma: Tumor cells are typically positive for Desmin, SMA, Myogenin, and MyoD1 [23], but negative for TFE3. While these features overlap with those of ASPS, the key distinction lies in the absence of TFE3 positivity in this tumor, which is a hallmark of ASPS, as well as the gene fusion profiles that differ between the two entities.