LPA and Stroke: The prospective FRENA registry demonstrated an increased risk for MI (adjusted HR 5.22; 95% CI 3.06–8.92), stroke (adjusted HR 8.96; 95% CI 4.41–18.21) and limb amputation (adjusted HR 3.20; 95% CI 1.36–7.52) in stable LEAD outpatients with Lp(a) between 30 and 50 mg/dL.