As shown in Fig. 3B and Additional file 1, compared with the control group, the neuronal necrotic and apoptotic rate significantly increased in the OGD model group; the infection of empty lentivirus in vehicle group further increased the neuronal necrotic and apoptotic rate after OGD; compared with the vehicle group, the neuronal necrotic and apoptotic rate was significantly decreased in the RFK( +) group (P < 0.01); while it was significantly increased in the RFK(-) group (P < 0.01). The gene discussed is RFK; the disease is infection.