However, its specific role in progression rather than relapses may be related to the fact that IL-6 has been found on the leading edge of chronic active MS lesions [16], has been implicated in the formation of meningeal follicles [17], which have been postulated to underpin the smouldering damage that originates from the meninges, and has been postulated to be one of the key cytokines responsible for the shift in the overall inflammatory milieu from that of repair to progressive neurodegeneration [18]. Here, IL6 is linked to myeloid sarcoma.