HMOX1 and non-small cell lung carcinoma: To explore the molecular mechanism underlying the progression of non-small-cell lung cancer (NSCLC) induced by CYP1A1 overediting, a Flag-tagged CYP1A1-edited probe and a control probe were used to identify the interaction between HO-1 and CYP1A1 or CYP1A1_I462V in 293T cells, respectively, through co-IP assay (Fig. 7A).