On the basis of previous findings linking CYP1A1 to the PI3K-Akt signaling pathway in breast and prostate cancer [34, 38], we observed that the CYP1A1_I462V mutant increased both total Akt levels and Akt phosphorylation in cells expressing edited CYP1A1 constructs as well as A549I462V cell lines. This evidence concerns the gene CYP1A1 and prostate carcinoma.