On the basis of previous findings linking CYP1A1 to the PI3K-Akt signaling pathway in breast and prostate cancer [34, 38], we observed that the CYP1A1_I462V mutant increased both total Akt levels and Akt phosphorylation in cells expressing edited CYP1A1 constructs as well as A549I462V cell lines. Here, CYP1A1 is linked to Familial prostate cancer.