EDNRA expression in vascular tissue and endothelin-1 levels in the blood are altered in atherosclerosis (Fan et al, 2000; Stölting et al, 2020) and EDNRA antagonists can attenuate the progression of coronary atherosclerosis lesions (Yoon et al, 2013). The gene discussed is EDNRA; the disease is coronary atherosclerosis.