POF, typically characterized by absent menses, hypergonadotropinism, and hypoestrogenism in women under 40 [163], is diagnosed using criteria such as: (i) amenorrhea lasting at least 4 months, (ii) reduced serum E2 levels, and (iii) elevated serum FSH levels (exceeding 40 IU/L in at least two samples taken several weeks apart) [164, 165]. The gene discussed is BRD2; the disease is amenorrhea.