AKT1 and cancer: In addition, flavonoids, as pro-oxidants factors, could repress cancer cells proliferation by inhibiting the epidermal growth factor receptor/mitogen activated protein kinase, phosphatidyl inositide 3-kinases, protein kinase B, CatB, and nuclear factor kappa-light-chain-enhancer of activated B cells (Vidal-albalat and González 2016; Kopustinskiene et al. 2020).