To test the role of Tet1/3 in CD8 effector T-cell fates during acute LCMV-Armstrong infection, we challenged RorcCreTg Tet1/3fl/fl mice (hereafter referred to as Tet1/3cDKO), in which double-positive thymocytes and their αβ CD4+ and CD8+ single positive progenies are deficient in Tet1 and Tet3 (Eberl and Littman, 2004; Issuree et al, 2018). This evidence concerns the gene CD4 and infection.