As autocrine IL-2 is not required for effector CD8 T-cell differentiation during primary infection (Toumi et al, 2022) and considering the lack of SLEC/TEM phenotypes in Tet3 cKO mice, we conclude that Tet3 is not sufficient to restrict SLEC/TEM CD8 T-cell differentiation and that Tet1 or the combined actions of Tet1 and Tet3 are likely required for this process. The gene discussed is CD8A; the disease is infection.