In fact, it significantly inhibited GSK3α (Fig. 3A), GSK3β (Fig. 3B), mTOR (Fig. 3C), p70S6K (Fig. 3D), RPS6 (Fig. 3E) and TSC2 (Fig. 3F) phosphorylation after 24 h, at concentrations corresponding to the experimental IC50, compared with IgG1 control, in all DLBCL cells, except for a lower, not significant, reduction of phospho-mTOR levels in OCI-LY3 cells (Fig. 3C). This evidence concerns the gene TSC2 and diffuse large B-cell lymphoma.