We showed that pre-treatment of SARS-CoV-2 (de21) with 20 μg/ml wild-type ACE2-Fc efficiently inhibited infection of primary ALI cultures, as evidenced by immunohistochemical staining for the SARS-CoV-2 nucleocapsid protein as well as quantification of both intracellular and extracellular viral RNA (Fig. 3). The gene discussed is ACE2; the disease is infection.