Strikingly, immunohistochemical staining of lung sections with antibodies to the SARS-CoV-2 nucleocapsid protein revealed that repeated post-infection treatment with wild-type ACE2-Fc led to a marked reduction in the number of virus-infected cells, whereas the extent of SARS-CoV-2 infection in the lungs of hamsters treated with mutACE2-Fc was similar as in the vehicle-treated group (Fig. 6). Here, ACE2 is linked to infection.