In our study, we found that KIF18A inhibition by AM-1882 enhanced infiltrating of CD45+ leukocytes, CD3+ T cells, CD3+CD8+ Cytotoxic T (Cyto T) cells, and decreased infiltrating of CD25+FoxP3+ regulator T (Treg) cells in CIN+ colorectal tumors. Here, CD8A is linked to cervical squamous intraepithelial neoplasia.