CAST and hepatocellular carcinoma: Notably, while mice harboring TXNIP-OE HCC-1954 cells tend to die prematurely without significant tumor burden or visible metastasis, all mice harboring CAST-KD_TXNIP-OE HCC-1954 cells survived for the entire experiment (Supplementary Fig. 5E), suggesting that CAST depletion could diminish the lethality caused by TXNIP-OE HCC-1954 tumors.