Basal OCR decreased from 47% in TXNIP-OE HCC-1954 cells to 32% in CAST-KD_TXNIP-OE HCC-1954 cells, concurrent with a decrease in ATP production from 32% in CAST-KD_TXNIP-OE cells to 23% in CAST-KD_TXNIP-OE HCC-1954 cells (Fig. 4G; Supplementary Fig. 5F). The gene discussed is CAST; the disease is hepatocellular carcinoma.