In pancreatic ductal adenocarcinoma (PDAC), CBX7 inhibits tumor progression by upregulating PTEN (Phosphatase and Tensin Homolog) expression, thereby negatively regulating the PI3K/AKT signaling pathway in Panc-1 and MIA PaCa-2 cell lines, as well as in nude mice [107]. Here, PTEN is linked to pancreatic ductal adenocarcinoma.