In GC, CBX7 is overexpressed and acts as an oncogene by enhancing cancer stem cell-like properties via the AKT-NF-κB-miR-21 pathway and downregulating the tumor suppressor p16, which promotes proliferation, invasion, and chemotherapy resistance in gastric cancer cell lines, consistent results were similarly obtained in mouse models [106]. The gene discussed is CBX7; the disease is cancer.