In vitro studies have shown that CBX2 can promote tumor growth and invasiveness by activating the PI3K/AKT pathway, a signaling cascade inducing phosphatidylinositol 3-kinase (PI3K), which phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) to generate PIP3. Here, AKT1 is linked to neoplasm.