Mutations in the TP53 gene reported to occur in 62% of high-grade ovarian serous carcinomas are distributed in all coding exons with a strong predominance in the DNA-binding domain region (referred to as hotspot residues in between of 94 and 292), which results in the abrogation of the sequence-specific DNA binding by p53 [13, 14]. Here, TP53 is linked to ovarian serous carcinoma.