Assessment of germline variants in 141 cancer predisposition genes among 51 patients revealed 13 heterozygous (likely) pathogenic variants (PGVs) in 13/51 patients (25%), 8 thereof in autosomal dominant cancer predisposition genes (3× BAP1, ATM, BRCA2, CHEK2, NF1, SDHB) and 10 in HR relevant genes (see Supplementary Data 5 and 6, available at https://doi.org/10.1016/j.esmoop.2025.104532). This evidence concerns the gene CHEK2 and cancer.