Loss of heterozygosity (LOH) of the wild type allele occurred in 5/13 patients (38%) with PGVs in genes ATM, BAP1, BRCA2, NBN and NF1. LOH in NF1, associated with tumors in neurofibromatosis type I, had not yet been reported in mesothelioma. The gene discussed is BRCA2; the disease is mesothelioma.