NLRFamily, PyrinDomain Containing3(NLRP3) and Absent in Melanoma 2 (AIM2) inflammasomes are best known so far for their involvement in T2D [6,7].Several metabolic DAMPs such as (ROS, disrupted lysosomal trafficking, aberrant ionicflux, and cholesterol crystals)lead to assembly of inflammasome components, i.e., NLRP3/AIM2, apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1,subsequentlyreleasing inflammatory cytokinesIL-1β and IL-18,andamplifying the inflammatory cascade [8]. The gene discussed is AIM2; the disease is type 2 diabetes mellitus.