We developed a low-dose STZ and HFD-induced diabetic mouse model having pathological characteristics similar to the human diabetic phenotype [25].Previous studies have reported that PTP1B is a key negative regulator of insulin pathway leading to insulin resistance, hyperglycemia and dyslipidemia [26,27].Consistent with this report, our study also showed increased BGL and oxidative stress as well as reduced body weight of STZ group mice. Here, PTPN1 is linked to Insulin resistance.