We developed a low-dose STZ and HFD-induced diabetic mouse model having pathological characteristics similar to the human diabetic phenotype [25].Previous studies have reported that PTP1B is a key negative regulator of insulin pathway leading to insulin resistance, hyperglycemia and dyslipidemia [26,27].Consistent with this report, our study also showed increased BGL and oxidative stress as well as reduced body weight of STZ group mice. This evidence concerns the gene LRBA and Hyperglycemia.