IGHE and mastocytosis: These can be life threatening in 90% of cases of mastocytosis-affected subjects who are not protected by immunotheraphy, who are not carrying an epinephrine auto injector and who may display basic hyperreactivity, described as both spontaneous or consequent to exogenous triggers (IgE or sometimes not IgE mediated) [9, 10, 14–19, 22, 23].