Anaphylaxis is a life-threatening condition resulting from the immunoglobulin IgE-mediated release of vasoactive and inflammatory compounds from mast cells and basophils, which occurs after the interaction of specific allergenic antigens (drugs, foods, hymenoptera venoms, contrast reagents and allergen extracts) and IgE in previously sensitized patients, with the involvement of two or more body systems, typically skin-mucosal tissue and the respiratory, cardiovascular and gastrointestinal systems [1, 2]. Here, IGHE is linked to anaphylaxis.