In any case, the medico-legal post-mortem diagnosis of anaphylaxis, and not only in cases of patients suffering from mastocytosis, should not be made on the basis of tryptase alone but must be contextualized within clinical history, autopsy findings and ancillary tests, such as specific IgE [1, 2, 27, 36–38, 40, 41]. Here, IGHE is linked to mastocytosis.