Coroners and forensic pathologists are aware that, in cases of anaphylactic death, data on the serum tryptase levels of living patients are not normally demanded by clinicians during acute phases and so are not available for post-mortem comparison; during emergency situations, in cases of life-threatening anaphylaxis, the standard laboratory procedures used to detect and quantify tryptase and IgE take a relatively long time and are not routinely performed in acute pre-mortem phases because they are considered of no help in emergency clinical diagnosis and treatment [1, 2]. Here, IGHE is linked to anaphylaxis.