MTOR and fragile X syndrome: Interestingly, the mRNAs of both PTEN and mTOR are a target of FMRP (Darnell et al. 2011), and hyperactivity of the mTOR complex has been found in juvenile Fmr1 KO mice (Sharma et al. 2010), as well as in FXS patients (Hoeffer et al. 2012).