Loss‐of‐function mutations in Abhd12 cause the neurological disease PHARC (Polyneuropathy, Hearing loss, Ataxia, Retinitis pigmentosa and Cataract), and so the upregulation in Abhd12, noted here (Figure 8H), could potentially be a neuroprotective response to the activation of chronic stress‐induced signalling pathways in the hippocampus of CRSTumor versus CANTumor mice. The gene discussed is ABHD12; the disease is cataract.