IL10 and cancer: We speculate that the CANReject and CRSReject groups of mice (i.e., 19% of those inoculated with Py230 cancer cells) may have mounted a robust immunogenic cell death (ICD) response that triggered a heightened ‘anti‐inflammatory’ physiological state which yielded increased levels of IL‐10 in the brain (and potentially other organ systems) with the function of protecting the host against any harm that could be caused by a systemic anti‐tumoural defence response (Fucikova et al. 2020; Showalter et al. 2017).