Additionally, TGF‐β has been linked to the differentiation of immunosuppressive Tregs, Bregs, Cancer‐Associated Fibroblasts (CAFs), and N2 neutrophils.[24] Similarly, WNTs promote the polarization of Tregs and CAFs.[25] Collectively, we postulated a cellular network in which C1q secretion by TAMs triggers DNA hypermethylation in tumor cells, leading to the enhanced secretion of WNTs and TGF‐β, thereby shaping a more pronounced immunosuppressive TME. The gene discussed is TGFB1; the disease is cancer.