Aberrant DNA methylation is recognized as a crucial event in tumorigenesis, with DNA methylation inhibitor therapy not only impeding malignancy in tumor cells but also modulating the function of immune cells involved in adaptive immunity.[21] Specifically, DNA methylation in the vicinity of the TSS hinders transcription, whereas methylation in the exon region reinforces transcription.[22] Notably, genes belonging to the WNT and TGF‐β families exhibited methylation around the exon region in our data. The gene discussed is TGFB1; the disease is neoplasm.