Prior research has demonstrated that TAMs can enhance the malignant phenotype and stemness of tumor cells through the secretion of TGF‐β, C‐C motif chemokine ligand 2 (CCL‐2), and interleukin‐6 (IL‐6).[20] In our study, we unveiled a novel mechanism whereby TAMs secreted C1q to drive tumorigenesis. Here, TGFB1 is linked to neoplasm.