IL1B and mood disorder: Furthermore, inflammation may alter the connectivity between the mPFC and other brain regions, such as the amygdala and hippocampus, by affecting neuroplasticity and synaptic pruning, which in turn exacerbates mood disorders.[29, 30, 31] In this study, LPS treatment induced microglia activation and overexpression of the pro‐inflammatory cytokines TNF‐α and IL‐1β in the mPFC.