developed a SERS optophysiological nanoneedle for simultaneous sensing both CO32− and pH in a live mouse brain.[18] In addition, we developed pH‐responsive SERS probes to delineate the invasive margins of gliomas.[19] Hence, a SERS probe capable of simultaneously determining intracellular GSH and H2O2 holds promise in the identification of IDH1 genotypes of glioma cells. The gene discussed is IDH1; the disease is glioma.