One study demonstrated that IDH mutations, when occurring alongside alterations like 1p/19q co‐deletion, profoundly impact glioma metabolism and tumor behavior.[32] Even though the clinical relevance of visualizing the spatial heterogeneity of IDH1 mutation remains unclear, we anticipate that it provides a valuable parameter in intraoperatively evaluating tissue malignancy and invasiveness. This evidence concerns the gene IDH1 and glioma.