However, in the dataset obtained from our hospital, METTL3 and WTAP were poor prognostic factors for AML (Figure 2A,B), and multivariate Cox regression analysis showed that METTL3 was an independent prognostic factor (HR: 5.635, 95% CI: 1.147–27.694; p = 0.033) (Table 1). This evidence concerns the gene METTL3 and acute myeloid leukemia.