We observed no significant difference in the percentage of cells positive for the methyltransferases METTL3 and METTL14 or WTAP, or the demethylases FTO and ALKBH5 between primary AML samples and R/R‐AML samples, but this percentage was significantly greater than that in CR‐AML samples (Figure 1C–G), suggesting that m6A RNA modification enzymes may have prognostic value. This evidence concerns the gene METTL14 and acute myeloid leukemia.