These isoforms form heterodimers with a common regulatory subunit, CAPNS1, essential for their catalytic activity.[31] While calpain‐1 and calpain‐2 are predominantly present across most vascular systems, other isoforms exhibit tissue specificity and have been less studied in vascular regulation due to their low expression in the healthy aorta.[30] The present study demonstrates a significant elevation of calpain‐2, but not other isoforms, in both human TAD samples and mouse AD models. The gene discussed is CAPNS1; the disease is Alzheimer disease.