Abnormal inflammatory response is a critical characteristic of IVDD.[23] Several critical genes are involved in glycolysis, including glucose transporters 1/3/4 (GLUT1/3/4), HK2, phosphofructokinase (PFK), phosphoglycerate Kinase 1 (PGK1), pyruvate kinase M2 (PKM2), LDHA, and monocarboxylate transporter 4 (MCT4).[24] We performed bulk mRNA sequencing with human NPC degeneration model using by Interleukin 1β (IL‐1β, 10 ng mL−1). The gene discussed is PKM; the disease is nasopharyngeal carcinoma.