Modulation of metabolic actions has been recommended for the treatment of various diseases such as OA, tumor response to chemotherapy, and immune regulation.[45, 46] In OA, inhibition of glycolysis showed a protective effect against chondrocyte degeneration.[47] Manoj et al.[48] noted that LDHA inhibition by FX11 could reduce catabolic activity and oxidative stress, indicting the importance of metabolic–inflammatory axis in regulating OA. Here, LDHA is linked to neoplasm.