miRNAs with the length of 22–25 nucleotides are the major group of small non‐coding RNAs, which participate in the development of many diseases including intervertebral disc degeneration via directly inhibiting the mRNA levels for target genes.[34] Therefore, we first sought the potential bridge miRNAs that targeting SIRT3 using the algorithm Target Scan from Target Scan Human 7.2, mirDIP, and miRDB. Here, SIRT3 is linked to Intervertebral disk degeneration.