In addition to ATP production, metabolic remodeling is closely correlated with cellular dysfunction, including the tumorigenesis, activation of immune cells, regulation of mitochondrial dysfunction, and ECM modulation.[37, 38, 39] In chondrocytes of patients with osteoarthritis (OA), anaerobic glycolysis is enhanced and mitochondrial function is decreased.[15] Li et al.[17] reported that programmed activation of GLUT1 could result in the accumulation of AGEs and ECM degradation in articular cartilage. This evidence concerns the gene SLC2A1 and osteoarthritis.