Gq and G11 proteins are functionally redundant (Malbon, 2005; Wettschureck and Offermanns, 2005), and the constitutively active mutants Gq-Q209L and G11-Q209L activate the same signaling pathways in the context of uveal melanoma (Annala et al., 2019; Lapadula et al., 2019). Here, WHR1 is linked to uveal melanoma.