APOB and familial hyperaldosteronism: While a number of other pathogenic variants in APOB causing the clinical phenotype of FH have been reported, as shown in Figure 2, in the 2018 report, 353 variants in APOB had been published, of which 35 (10%) were designated as pathogenic with the majority of published APOB variants designated benign, likely benign or VUS (Iacocca et al.