After 12 weeks western diet feeding (Figure 1A), hIGFREO/ApoE−/− developed significantly less atherosclerosis in the thoraco-abdominal aorta (Figure 1B), aortic arch (Figure 1C), and aortic sinus (Figure 1D), compared with ApoE−/− littermates. The gene discussed is APOE; the disease is atherosclerosis.