CDH5 and Ureteral obstruction: Liang et al. have shown that mice with endothelial deletion of IGF-1R exhibit increased renal leucocyte infiltration after ureteric obstruction, associated with increased phosphorylation of the endothelial cell–cell junction protein VE-Cadherin at Y731.21 Moreover, Higashi et al. have found that deletion of endothelial IGF-1R increases atherosclerosis in mice, associated with a trend towards increased vascular leakage in vivo and decreased expression of multiple EC junction proteins in vitro.