IL2 and herpes labialis: For IL-2, a meta-analysis revealed that the most commonly reported side effects were pain and swelling, fever, and flu-like symptoms (25%–85%), as well as mild nausea and emesis (40%), consistent with our data.25 While two cases of herpes labialis have been reported in our cohort under treatment with T-VEC, IL-2 is not associated with the risk of viral transmission.