Indeed, signature genes responsible for the progression to CRC in patients with ulcerative colitis have been proposed, including WFDC2, TTLL12, THRA, EPHB3 [12], ARID1A, FBXW7, KRAS, RNF, APC, P53 and SMAD4 genes [13]. The gene discussed is TP53; the disease is colorectal carcinoma.